COVID-19 Coronavirus UK and World News Update 13th / 14th January 2021.
UK official data is broken today. I'll seamlessly edit it in and add it in the comments when it is published, but there have been 48,682 more positive cases in the latest 24 hour reporting period.
A "data processing issue" is to blame according to Public Health England.
Rep. Of Ireland 159,144 cases and 2,460 losses of life. (Not yet reported today.)
There have now been a total of 93,229,269 reported cases worldwide. The number of people who have lost their lives worldwide to COVID-19 is 1,994,359. Already 66,549,524 people have recovered.
There are now 3 "lineages of concern" or mutated variants which we have to keep an eye on - well, really it's mostly the scientists keeping an eye on them.
1) - The UK variant B.1.1.1 which has now been located in at least 51 countries, and is the most populous strain in the UK, and rising fast in Denmark. This strain has 2 important mutations - N501Y spike protein mutation, and a double deletion or missing part of the code at points H69 and V70. We believe this makes it around 50-70% more transmissible and removes an attack option for most current vaccines, but shouldn't make them less effective overall.
2) - The South African variant B.1.351/ 501Y.V2 has an identical gap in it's programming to the UK variant (69/70 deletion), the spike protein N501Y and a couple of other spike mutations. One of the other mutations, E484K was shown to 'escape' natural antibodies in a single patient, so it is a bit worrying and trials are ongoing to check it isn't resistant to vaccines. Like the UK variant, it is assumed to be more transmissible, but not more personally deadly. It has been spotted in at least 16 countries, but is far less prevalent than the UK strain at the moment.
3) - The Brazilian variant P1 (20J/501Y.V3.) was first discovered in 4 travellers returning to Japan from Brazil, and has since been found in several Brazilian cases.
"We have detected a new variant circulating in December in Manaus, Amazonas state, north Brazil, where very high attack rates have been estimated previously. The new lineage, named P.1 (descendent of B.1.1.28), contains a unique constellation of lineage defining mutations, including several mutations of known biological importance such as E484K, K417T, and N501Y."
Because it has the same N501Y spike protein mutation as the other two, the obvious worry is that it is also likely to be more transmissible.
Because it has E484K like the South African variant, it is also being watched incredibly carefully until we are sure current vaccines will do the job.
No-one seems willing to say publicly yet what they believe K417T is likely to do, but it is another spike protein of concern.
(Remember vaccines can easily be tweaked, but it takes about 6 weeks plus the time, cost and resources needed to manufacture and distribute new vaccines).









